This book constitutes the proceedings of the 11th Enterprise Engineering Working Conference, EEWC 2021, which was held online on November 12, 2021, and December 16-17, 2021. EEWC aims at addressing the challenges that modern and complex enterprises are facing in a rapidly changing world. The participants of the working conference share a belief that dealing with these challenges requires rigorous and scientific solutions, focusing on the design and engineering of enterprises. The goal of EEWC is to stimulate interaction between the different stakeholders, scientists as well as practitioners, interested in making Enterprise Engineering a reality. The 5 full papers and 3 short papers presented in this volume were carefully reviewed and selected from 16 submissions. The volume also contains 2 keynote papers.