This two-volume book constitutes the post-conference proceedings of the 5th International Conference on Advances in Computing and Data Sciences, ICACDS 2021, held in Nashik, India, in April 2021.* The 103 full papers were carefully reviewed and selected from 781 submissions. The papers in Part I and II are centered around topics like distributed systems organizing principles, development frameworks and environments, software verification and validation, computational complexity and cryptography, machine learning theory, database theory, probabilistic representations database management system engines, data mining, information retrieval query processing, database and storage security, ubiquitous and mobile computing, parallel computing methodologies, and others.  *The conference was held virtually due to the COVID-19 pandemic.