This book constitutes the refereed proceedings of the 16th Colombian Congress on Computing, CCC 2022, held in Armenia, Colombia, during October 17-21, 2022The 12 full papers included in this book were carefully reviewed and selected from 40 submissions. They topics of this volume include software engineering and IT architecture, human-computer interaction, cybersecurity and information security, image processing and computer vision, multimedia, artificial intelligence and robotics, education and ICT, data, information and knowledge, distributed systems and large-scale computing, and formal methods in computer systems, among others.