This book constitutes the proceedings of the 35th International Conference on Advanced Information Systems Engineering, CAiSE 2023, which was held in Zaragoza, Spain, during June 12-16, 2023. The 36 full papers included in these proceedings were selected from 161 submissions. They were organized in topical sections as follows: Cyber-human and cyber-physical systems; requirements engineering; IoT; environmental applications; process mining; event-driven process mining; ontology and knowledge representation; model-driven approaches; process monitoring; conformance, compliance and workarounds; data-centric approaches; privacy and security; explainable AI; service-related approaches.