This book constitutes the proceedings of the 16th International Conference on Advanced Data Mining and Applications, ADMA 2020, held in Foshan, China in November 2020. The 35 full papers presented together with 14 short papers papers were carefully reviewed and selected from 96 submissions. The papers were organized in topical sections named: Machine Learning; Text Mining; Graph Mining; Predictive Analytics; Recommender Systems; Privacy and Security; Query Processing; Data Mining Applications.