Meet six women who shouldn't have anything in common. Cristal - Flamboyant and self-indulgent, she's working on her third husband and a biological clock that's gone into overdrive. Melvina - An aging academic's wife watching her reality crumble. Morena - Always searching for Mr. Right, she starts to think that maybe her life is missing more than a man. Leanne - A Southern Belle raising a brood of kids and trying to fit in with her old-world Italian family. Janice - The perfectly put-together professional with a nagging sense that something in her life needs to change. Clarissa "Red" - A recent college grad searching for a practical job, but not quite ready to give up her dreams. Six lives that might never have crossed, forever changed by unlikely bonds of friendship.